Job Description

Job Summary

We are seeking a highly motivated Research Scientist to join our Immune Profiling Platform at Huntsman Cancer Institute. Our basic and translational research program is dedicated to advancing immunotherapy through comprehensive immune microenvironment characterization. This position will play a key role in implementing and optimizing cutting-edge technologies, including single-cell sequencing, multiparameter flow cytometry, and other immune profiling approaches, to drive innovative research in immuno-oncology, autoimmune disease, and infectious diseases. The ideal candidate will have expertise in immune profiling techniques, strong analytical skills, and a collaborative mindset to work closely with multidisciplinary teams, including clinicians and computational biologists. This role offers an exciting opportunity to contribute to translational research aimed at improving immunotherapeutic strategies.

Qualifications

1. PhD, MD, or MD/PhD Hands-on experience with single-cell sequencing, multiparameter flow cytometry, spectral flow, CyTOF, or spatial transcriptomics. Strong data analysis skills, including proficiency in FlowJo, R, Python, or other bioinformatics tools. Familiarity with immunotherapy approaches and immune microenvironment characterization. Experience with next-generation sequencing (NGS) and genome editing is a plus Basic computational skills to analyze and interpret next generation sequencing and multi-dimensional flow cytometry data Excellent written and oral communication skills Strong organizational skills, including the ability to handle a variety of tasks in a fast-paced environment required Strong analytical and problem-solving abilities with a data-driven approach Ability to work both independently and collaboratively in a fast-paced research and manufacturing environment. Please include a CV, a letter of interest and a list of three references in the application. Minimum two-year commitment is required .

This job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

Essential Functions

1. Technology Development & Optimization – Establish, optimize, and validate cutting-edge immune profiling techniques, including single-cell RNA sequencing, multiparameter flow cytometry, and spatial transcriptomics.
2. Experimental Design & Execution – Develop and execute immune profiling experiments to analyze immune cell composition, activation states, and functional phenotypes in various disease models.
3. Data Analysis & Interpretation – Process, analyze, and interpret high-dimensional data from flow cytometry, single-cell sequencing, and imaging-based assays, using tools such as FlowJo, R, Python, or other bioinformatics platforms.
4. Collaboration & Cross-Disciplinary Integration – Work closely with clinicians, computational biologists, immunologists, and bioinformaticians to integrate immune profiling data into broader research initiatives focused on immunotherapy.
5. Sample Processing & Quality Control – Handle and process human and animal tissue samples, including cell isolation, staining, and sorting, ensuring high-quality and reproducible results.
6. Instrumentation Maintenance & Troubleshooting – Maintain, calibrate, and troubleshoot immune profiling instruments
7. Scientific Writing & Presentation – Prepare reports, manuscripts, and presentations summarizing experimental findings for publications, conferences, and grant applications.
8. Grant & Funding Support – Assist in developing grant proposals and research funding applications by providing technical expertise and data supporting immune profiling-based studies.
9. Training & Mentorship – Assist in mentoring junior researchers and maintaining lab operations.

This job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

Problem Solving

1. Must possess a high level of initiative and the ability to work with little supervision while adhering to Standard Operation Procedures.
2. Must have excellent written, documentation, and oral communication skills.
3. Must possess strong interpersonal, organizational, and analytical skills, including the ability to handle a variety of tasks in a fast-paced environment.
4. Proactive in identifying problems and solutions to address them.
5. Must be an exceptional team player.
6. Address scientific and technical challenges related to immune and cancer cell characterization

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